I have run stock clamps on my bike in the past and now run
pro taper 22.5mm rubber mount clamps. Been that way for about 2 years now. Changing the clamps was definitely a pretty big difference. It made my bike feel completely different, similar to making suspension modifications.
In stock form, the Yamaha is a very neutral feeling bike, this is why a lot of people love them. They are extremely easy to ride and keep stable. However, once you start going fast (I don't mean in a straight line but making fast, sharp turns), that stability begins to slow you down. At least it did with me. So I went on a mission to improve the responsiveness of my bike. At first, the basics were done, stock tires were changed, clickers and preload adjusted. These things definitely helped, then finally I got my suspension done by a local shop and was hooked on suspension work. After riding that setup for a while, I found some Pro Taper 22.5mm triple clamps on sale for the 08+ yz250's. I quickly jumped onto the deal and soon had a box of parts at my front door. Everything was installed and the bike was taken to the track the next day.
The change felt so significant that it was actually awkward to ride my bike at first. Pushing out of corners was replaced by the front tire falling into the turn and sticking to it no matter how fast I was going. I could just lean the bike over and as long as I had the traction, it would rail corners. I actually gave myself whiplash at one point because I took a corner so fast at a local track. It was an extremely confidence boosting upgrade once I got used to it. Ever since then, I've been making little suspension changes here and there getting my bike closer to the point of perfection.
Current suspension specs for a 195lb 6'3" novice/intermediate motocross rider:
.46 fork springs (4mm down in clamps)
5.1 shock spring (98mm race sag)
I will be going to stiffer springs soon
Race Tech G2-R fork/shock valves
Fork floating piston drilled to prevent cracking due to hydrolocking
Rear shock high speed adjustment valve porting increased to 08+ specs to reduce hydrolocking during accel/braking bumps
Building a B-kit through Factory Connection hopefully over the summer!
There are a few things to note. All of those "positives" that I mentioned definitely came with their share of negatives. If you ride in the dunes or sandy conditions a lot, I would suggest against these clamps. They tend to make the bike oversteer quite a bit in those conditions. While the overall steering responsiveness did improve, this also means that you must be more aware and alert while riding the bike. Precise maneuvers are rewarded more and carelessness is not ignored. Riding at high speed is more unstable.
That's been my experience with different offset clamps. Let me know if I can provide any additional insight!