650 does and the DRZ400s does as well. DS's are heavier than the dirt only bikes for a reason.
You are asking to do some serious miles on the WR. Most people you read about do 100 street miles a month, not 200 a week (what you are proposing) and are run very carefully, or rebuilt quite often.
Like was mentioned, you CAN do it. But it wouldn't be fun or advisable. Pick up a $600 UJM bike for running back and forth to work. Throw a shit-ton of miles on that and keep a WR for dirt or short street trips.
Right after I bought my 04 I put street stuff on it and went for a mostly street afternoon DS ride following my dad on his DRZ400s. Let's just say one of us was ready to be done after 25 minutes and it wasn't him. My SSS hurt for 2 days after.
I have had 3 DRZ400S and none of them have a cush drive hub. They have been quite good for commuting (total mileage on the 3 DRZ400S is about 18,000 miles). I currently have my 2005 DRZ400s set up with a 15/41 sprocket combo and it is ideal on the street. My dual sported WR450f would be gruesome on the street as a commuter bike. There is no perfect bike but a WR450f is far from an ideal commuter bike in any situation.